What does it mean to be human? From Plato to contemporary times, humanity is often bemused by a cognate understanding of personhood and what it means to be human. The dissertation engages personhood (human nature and identity) from two cultural traditions vis a vis human enhancement innovations that are prevalent in current society. The 21st century heralded rapid advancements in AI and technology which has presented several benefits and challenges. What it means to be human has been redefined in essentially biological and technological perspectives, what is herein proposed as the bio-techno-scientific mode of being human. This dissertation brings to limelight personhood in African and African American traditions as well as the Imago Dei within Christian theology as important lenses for foregrounding a more holistic, ethical, and wholesome definition of personhood. It proposes a four-fold paradigm for defining humanity, drawn from these two traditions, which can ultimately serve as a foundational crux and ethical framework for foregrounding human flourishing as a counterpoise to the non-beneficial transformational effects of AI and technological innovations, despite their immense benefits to humanity.