Between 1880 and 1920, American Protestantism was reshaped by converging waves of social and religious change. One of the most enduring and influential products of this period of change was dispensationalism, offering new, modern methods for readings texts (particularly the Bible) and structuring time (through elaborate interpretations of prophecy). Dispensational thinking emerged amidst popular beliefs about the power of quantification, classification, and scientific analysis to construct firm religious knowledge. Institutionally, dispensationalism thrived in the emerging fundamentalist networks, particularly those surrounding lightening-rod Bible teacher C.I. Scofield and his ubiquitous Scofield Reference Bible. The latter, the best-selling reference Bible in American history, codified and popularized the ideas of dispensationalism. This dissertation examines the cultural and religious contexts that produced and nurtured dispensationalism, and its subsequent systemization and propagation through Scofield’s religious networks and annotated Bible.